What toxin mediates EHEC diarrhea? What is the mechanism of action?
Answer: Shiga-like toxin (verocytotoxin) inhibits 28S component of the 60S ribosome subunit, inhibiting protein synthesis leading to cell necrosis of the intestinal epithelium and hemorrhagic colitis.
Mnemonic:
Shiga-like it's the 1960s
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