What is the mechanism of heat LT?
Answer: Constitutively activates Gs via adenosine diphosphate (ADP) ribosylation leading to constant activation of adenylate cyclase and high levels of cyclic adenosine mono-phosphate (cAMP). This causes increased secretion of Cl− ions from intestinal cells into the gastrointestinal (GI) lumen. Negative Cl− ions cause positively charged Na+ ions to follow. Water follows Na+ into the lumen leading to diarrhea.
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